Methods: We found that co-expression of Epo and EpoR may mediate developmental stagnation and induce proliferation of hemangioblastoma. The specimens were sectioned and subjected to routine histology, immunohistochemistry and molecular analyses. Ocular hemangioblastoma cells were microdissected in order to determine expression of Epo and EpoR transcripts using reverse transcription-polymerase chain reaction. Results: Tumorlet-like cells were identified in retinal and optic nerve hemangioblastomas. Co-expression of Epo and EpoR at both protein and messenger levels was detected in many hemangioblastoma cells. In addition, ocular VHL lesions expressed several stem cell markers including CD to various degrees.
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Aug 14, — That's how much share market value has been wiped out since the London-based chairman, Richard Gillingwater, issued a terse three-paragraph statement giving Formica his marching orders and naming Dick Weil as the sole CEO of the global funds manager. The decision to appoint Weil has triggered a prolonged sell-off. The stock has fallen on 10 of the 11 most recent trading days. David Rowe Local investors, who own about 40 per cent of the company, are angry and are voting with their feet.